(855) 940-4867

Greenbrook Logo

Don't let depression keep you in the dark

Greenbrook now offers Spravato®, the only FDA-approved ketamine-based psychedelic treatment for depression.

What is Spravato® ?

Spravato® is an FDA-approved nasal esketamine spray, a more specific form of ketamine designed to treat depression. Ketamine is a drug that's primarily known for its uses as an anesthetic. You may have also heard of ketamine being used as a psychedelic street drug, but if it's used under the supervision of a doctor, it can be perfectly safe.


Spravato® was FDA-approved in 2019 for people with depression who have not experienced adequate improvement with antidepressant medications.


View Indications and Important Safety Information >

Coverage is key

Many major insurance companies cover esketamine nasal spray for depression. 


A benefit of having treatment at a Greenbrook center is that our Care Team does all the work for you regarding insurance. We assist all patients with the coverage and reimbursement process.

Learn more >

How does it feel?

During a Spravato® treatment, you may feel dizzy, or euphoric. Throughout your treatment, our Care Team will be onsite to assist you. 


After your two-hour session, you may be groggy and woozy. You will need to avoid hazardous activity for the remainder of the day. This includes operating a motor vehicle, so you will need someone to drive you home from treatment. By the next morning, most people are ready to resume their day with no restrictions. 

Learn more >

Where can I be treated?

We offer Spravato® esketamine nasal spray for depression at select Greenbrook centers.


Spravato® must be given at a certified REMS (Risk Evaluation and Mitigation System) center. The medical staff at Greenbrook's certified treatment centers are trained to prescribe, dispense, and administer Spravato®, and we have established processes and procedures in accordance with the REMS program.

Find a center near you >

How to get started

1. NO-COST CONSULTation

Learn about Spravato® nasal spray

You will first talk with one of our intake specialists, who will collect some basic information and arrange a meeting with one of our Consult Coordinators. The Consult Coordinator can meet with you in person, over video conference, or on the phone and will review your history and explain aspects of esketamine nasal spray treatment.

We focus on insurance so you don't have to

Your Consult Coordinator will also explain treatment payment options and review standard insurance plan criteria with you. We will coordinate with your health insurance provider to determine benefits.

IS SPRAVATO® COVERED BY INSURANCE?

Yes! Many major insurance companies cover ketamine-based depression treatment if you haven't gotten better after trying just TWO antidepressants.

More on Insurance Call Now for a Free Consultation Schedule a No-Cost Consultation

SHOULD I RECEIVE IV KETAMINE OR SPRAVATO® (NASAL ESKETAMINE)?

IV ketamine

  • Is not FDA-approved for the treatment of depression
  • Is not covered by many insurance companies
  • Is not offered at Greenbrook


Esketamine nasal spray (Spravato®)

  • Is FDA-approved for the treatment of depression
  • Is covered by many insurance companies
  • Is offered at Greenbrook

2. PRE-ASSESSMENT

Find out if Spravato® nasal spray is right for you

Next, you will meet with a Greenbrook affiliated provider for an evaluation, which includes questions about your history and symptoms. 

If the Greenbrook provider has determined that you are a candidate for esketamine nasal spray and you are ready to move forward, they will create your individualized treatment plan.

3. TREATMENT

You're ready to start feeling better!

At most Greenbrook centers, we try to book your Spravato® treatments to accommodate your schedule, whether morning or afternoon appointments work best for you.

After you arrive at the center, you will be placed in a reclining chair where you can sit back and relax. You will be handed a nasal spray device to self-administer. Your care team will supervise you for at least two hours. Afterward, you will need someone to drive you home from treatment. By the next morning, most people are ready to resume their day with no restrictions.

TYPICAL SPRAVATO®

TREATMENT SESSION

Ready to take the first step in your journey?

Find out if Greenbrook can help you or a loved one

Get started

Spravato® Treatment Phases

Treatment varies by individual. Some patients complete maintenance after the initial induction plan.

Induction

phase 1

Week 1-4

2 treatments a week

maintenance

phase 2

Week 5-8

1 treatment a week

maintenance

phase 3

Week 9+

1 treatment every 1-2 weeks

Your safety and comfort are our top priorities

Because Spravato® is a ketamine-based treatment for depression, during treatment, you may feel dizzy or euphoric. Our Care Team will be there to assist you throughout your treatment. Your blood pressure will be checked upon arrival, 40 minutes in, and before you leave.

After your two-hour treatment, you may be groggy and woozy. You will need to avoid hazardous activity for the remainder of the day, including operating a motor vehicle, so you will need someone to drive you home from treatment.

View Indications and Important Safety information

Where to find Spravato® for depression

GREENBROOK CENTERS ARE PRIVATE, RELAXING, & REMS-CERTIFIED

Curious about ketamine-based therapy for depression?

Your Consult Coordinator will help you find out if Spravato® is right for you!

curious about depression

Please provide the requested information on the form and Greenbrook TMS will contact you shortly. All information will be kept strictly confidential. We do not sell or share your information.

Free Consultation
+1
Were you or a loved one referred by a provider?
Greenbrook Opt-in

Spravato® FAQs

  • What's the difference between ketamine, esketamine, and Spravato®?

    Spravato® is nasal esketamine, a more specific form of ketamine designed to treat depression.


    Spravato® takes the effective part of ketamine and isolates that and then gets rid of the sedating part of ketamine that is not believed to be as important for depression.

  • Who is Spravato® nasal spray for?

    Spravato® esketamine nasal spray is FDA-approved for people with depression who have not experienced adequate improvement with antidepressant medications.

  • How long is a round of treatment?

    A typical round of esketamine nasal spray treatment is broken up into three phases: 

    • Induction, Week 1-4: 2 treatments a week 
    • Maintenance, Week 5-8: 1 treatment a week
    • Maintenance, Week 9+: 1 treatment every 1-2 weeks

    Treatment plan varies by individual. Some patients complete maintenance after the initial induction plan.


    Before each appointment, avoid eating for two hours and drinking large amounts of fluid for 30 minutes.


    Each session takes place at a private, spa-like Greenbrook center. Once you arrive, you'll sit in a comfortable recliner, and a technician will check your blood pressure. You will then complete a short form, after which you will be handed a nasal spray device to self-administer. We will go over how to administer the spray to yourself. 


    Throughout your treatment, our care team will be onsite to assist you. Your blood pressure is checked at the start of the session, 40 minutes into treatment, and before you leave the Greenbrook center. You must stay in the center for at least two hours. Ensure you have someone to drive you home, as you will not be able to operate a motor vehicle for the rest of the day. 

  • How much is a dose of Spravato®?

    Your Greenbrook provider will determine the dose of Spravato® based on your treatment plan. There will be 2-3 sprays self-administered in each nostril, depending on the dose prescribed by your provider.

  • What if Spravato® treatment isn't for me?

    That's okay! Our Consult Coordinators will help you decide if Spravato® depression treatment is right for you. If it isn't, Greenbrook also offers TMS therapy, which is a non-drug, non-sedating FDA-cleared treatment for depression. You can learn more about TMS by asking your Consult Coordinator or taking our TMS quiz. 

  • Can you take esketamine nasal spray while staying on medication?

    Yes. You must be on an antidepressant medication to receive Spravato® treatment.

  • Do I need to go to a hospital?

    No. Nasal esketamine must be given at a certified REMS (risk evaluation and mitigation system) center, such as a convenient outpatient Greenbrook TMS center. 


    The medical staff at Greenbrook’s certified treatment centers are trained to prescribe, dispense, and administer Spravato®, and we have established processes and procedures in accordance with the REMS program.

  • Does esketamine nasal spray work for anxiety?

    No. Esketamine nasal spray is FDA-approved for people with depression who have not experienced adequate improvement with antidepressant medications.

  • Who shouldn't take Spravato®?

    Greenbrook TMS recommends calling for more information on whether treatment is right for you. Below are some of the common contraindications, but each patient's journey is unique.

    • Uncontrolled hypertension
    • History of stroke or brain bleeds
    • Abnormal blood vessels at risk of bleeding, such as aneurysms or arteriovenous malformations (AVMs)
    • Sensitivity to esketamine or ketamine

    View Indications and Important Safety Information.

  • Is Spravato® covered by insurance?

    Yes! Many major insurance companies cover Spravato® depression treatment if you haven’t gotten better after trying two oral antidepressants. 

Share by: